No, they’re not the same. Andersen Windows sold at Home Depot are typically the 100 Series or similar retail lines, made of Fibrex composite material, sold as products for DIY or contractor installation.
Renewal by Andersen is Andersen’s separate, dedicated replacement division that sells directly to consumers through its own sales reps and installers, not through retail stores.
Renewal by Andersen windows use a different composite material (called Fibrex as well, but a proprietary formulation) and come with full-service, professional installation, custom measurements, and a company-backed installation warranty.
The Home Depot line is generally less expensive but offers fewer customization options and no dedicated installation service. Both come from the same parent company, Andersen Corporation, but target different customers and price points.